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</html>";s:4:"text";s:7044:"Geeta is resurrecting ancestral steroid receptors to understand the evolution of androgen, progestagen, and corticosteroid sensitivity in early receptor lineages. Reconstructing Ancient Proteins to Understand the Causes of Structure and Function.  Starting with a resurrected 500 million-year-old protein, researchers experimentally studied millions of other evolutionary paths it could have taken, revealing how chance shaped our biological history. We do this by phylogenetically reconstructing the histories of ancient proteins and then synthesizing, manipulating, and experimentally characterizing their biological functions and physical properties. Proc Natl Acad Sci U S A. (2010 Oct) PLoS Biol. Evolution of hormone-receptor complexity by molecular exploitation. (2013 Aug) Nat Rev Genet. Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW Proc Natl Acad Sci U S A. Articles Cited by. Our current model system is a gene family of great biological and biomedical importance. (2004 Oct) Nature. Elife. Luke is now a medical student at OHSU and remains, we believe, an awesome surfer and guitar player. View in: PubMed, Dean AM, Thornton JW. View in: PubMed, Sarkar IN, Thornton JW, Planet PJ, Figurski DH, Schierwater B, DeSalle R. An automated phylogenetic key for classifying homeoboxes. June is now completing her training at OSU’s School of Pharmacy. (2010 Jun) Curr Opin Struct Biol. June was a graduate student at UO and an NSF graduate research fellow. Science 301 (5640), 1714-1717, 2003. He graduated in August 2009 and is now a postdoc with Chris Marx at Harvard, where he is using experimental evolutionary approaches in bacteria to study molecular adaptation. doi: 10.7554/eLife.10147. Trading star-dust for nucleotides, Dave cannonballed into the world of evolutionary biology with a master’s degree in evolutionary genetics with Ben Evans, also at McMaster. She studied biochemistry, phylogenetics, and evolution at the University of Stellenbosch and the University of Cape Town and then was trained in molecular biology at the Yale School of Medicine before coming to the UO in early 2007. June studied the functional diversity of estrogen receptors in invertebrates and was the lead researcher for the lab’s publications on ERs in mollusks and annelids, as well as ERRs in nemerteans. View in: PubMed, Kolaczkowski B, Thornton JW. 2019 05 14; 116(20):9837-9842. Long-branch attraction bias and inconsistency in Bayesian phylogenetics. Effects of branch length uncertainty on Bayesian posterior probabilities for phylogenetic hypotheses. Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors. The following articles are merged in Scholar. Thornton JW, Need E, Crews D Nature. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. View in: PubMed, Starr TN, Thornton JW. Jamie completed her Ph.D. at Notre Dame, working with Alan Johnson on the function and evolution of death receptors involved in apoptosis. Aarti is currently studying the molecular mechanisms for the evolution of specificity and  cooperativity in DNA-binding transcription factors. Resurrecting ancient genes: experimental analysis of extinct molecules. Qinwen is interested in the evolution of DNA specificity and other functions in developmentally important transcription factors in Drosophila. 2007 Sep 14; 317(5844):1544-8. Exploring protein sequence-function landscapes. 2006 Oct; 23(10):1819-23. Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster. Mechanistic approaches to the study of evolution: the functional synthesis. She did her PhD in the evolutionary developmental biology in Caenorrhabditis species with Eric Haag at the University of Maryland. 2012;8(11):e1003072. 2010 Oct 05; 8(10). View in: PubMed, Siddiq MA, Thornton JW. View in: PubMed, Katsu Y, Cziko PA, Chandsawangbhuwana C, Thornton JW, Sato R, Oka K, Takei Y, Baker ME, Iguchi T. A second estrogen receptor from Japanese lamprey (Lethenteron japonicum) does not have activities for estrogen binding and transcription. Anderson DP, Whitney DS, Hanson-Smith V, Woznica A, Campodonico-Burnett W, Volkman BF, King N, Thornton JW, Prehoda KE 2004 Oct 21; 431(7011):980-4. View in: PubMed, Starr TN, Thornton JW. He spends an inordinate amount of time on his bicycle(s). View in: PubMed, Thornton JW, Kelley DB. John used his programming abilities to study the accuracy of methods for selecting models for phylogenetic analysis. View in: PubMed, Hochberg GKA, Thornton JW. Starr TN, Thornton JW Jamie served as the anchor of the Eugene lab. Finnigan GC, Hanson-Smith V, Stevens TH, Thornton JW 2010 Jun; 20(3):360-6. Thornton Lab website; Research Summary. View in: PubMed, Carroll SM, Bridgham JT, Thornton JW. Multinucleotide mutations cause false inferences of lineage-specific positive selection. Congratulations to Dr. Joe Thornton, winner of the 2019 Friend of Darwin Award by the National Center for Science Education for his contribution to evolution education. Our Mission Science, including genetics, plays a central role in many crucial issues of our time. Mol Biol Evol. He received his undergraduate degree in theoretical astronomy from the Arts and Science Program at McMaster University. Jackson is currently a research technician in Kirsten Lampi’s lab at Oregon Health & Science University, and will be applying for medical school in the fall. View in: PubMed, Bridgham JT, Brown JE, Rodríguez-Marí A, Catchen JM, Thornton JW. Before joining us, Jennifer did her Ph.D. with John McLachlan at Tulane, where she discovered that endocrine disrupters in the environment can interfere with the symbiosis of plants and nitrogen-fixing rhizobacteria and was a postdoc with Craig Jordan at Northwestern, where she worked on ligand- and tissue-specific coactivators for the estrogen receptor. A former member of UO’s IGERT training program in Evolution, Development, and Genomics, Bryan is now an Assistant Professor at the University of Florida. As a UO undergraduate, Molly isolated, cloned, and sequenced steroid receptors from basal chordates, including skate and lancelet. Science. Dean AM, Thornton JW joet1@uchicago.edu. Mol Biol Evol. Proc Natl Acad Sci U S A. 2005 Jun; 21(6):310-1. Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. 2016 Jan 7;5:e10147. 2007 Sep 14;317(5844):1544-8. Evolution of steroid receptors from an estrogen-sensitive ancestral receptor. Sean studied early glucocorticoid receptor evolution. We are particularly interested in understanding how uncertainty and heterogeneity in the evolutionary process affects the accuracy of current techniques for reconstructing phylogenies and inferring ancestral sequences. View in: PubMed, Thornton JW, DeSalle R. A new method to localize and test the significance of incongruence: detecting domain shuffling in the nuclear receptor superfamily. ";s:7:"keyword";s:21:"joe thornton uchicago";s:5:"links";s:940:"<a href="http://newdestinychurchpc.com/blog/article.php?tag=Leon-Spinks-6bb478">Leon Spinks</a>,
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